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0001 TY  - JOUR
0002 T1  - A continuous flow system (CFS) for chronic exposure of aquatic organisms
0003 AU  - Sanni, S.
0004 AU  - ØYsæd, K.B.
0005 AU  - Høivangli, V.
0006 AU  - Gaudebert, B.
0007 AB  - Effect studies on marine life are changing focus from acute lethal effects to long term sublethal effects. There is a need for laboratory test systems that can facilitate continuous supplies of test substances at sublethal concentrations. Stability and reproducibility of the test solutions and application of test substances in mixtures are required. With the Continuous Flow System (CFS) described, the aim has been to make a flexible tool adjustable to a wide range of studies. Thus, test solutions and dispersions of substances poorly miscible in water can be made in various ways, using different methods and devices for substance injection, mixing and further conditioning. More than one species of organisms can be tested simultaneously. The system can be run both with freshwater and seawater. Presently the system is used for bioaccumulation and biomarker studies related to impacts of oil industry discharges of produced water off shore. This paper presents the main features and functional parts of the system and some result examples.
0008 JF  - Marine Environmental Research
0009 VL  - 46
0010 IS  - 1-5
0011 SP  - 97
0012 EP  - 101
0013 PY  - 1998///
0014 KW  - biological marker
0015 KW  - fresh water
0016 KW  - industrial effluent
0017 KW  - sea water
0018 KW  - ecotoxicology
0019 KW  - laboratory method
0020 KW  - pollution effect
0021 KW  - sublethal effect
0022 KW  - aquatic fauna
0023 KW  - aquatic flora
0024 KW  - bioaccumulation
0025 KW  - conference paper
0026 KW  - environmental monitoring
0027 KW  - flow
0028 KW  - laboratory test
0029 KW  - long term exposure
0030 KW  - nonhuman
0031 KW  - oil industry
0032 KW  - reproducibility
0033 N1  - Times Cited: 7, Export Date: 12 November 2004, Record Source: Scopus
0034 ER  - 
0035 
0036 TY  - JOUR
0037 KW  - Bioactive compounds
0038 KW  - Bioprospecting
0039 KW  - Evolution
0040 KW  - Metazoa
0041 KW  - Urmetazoa
0042 T1  - Porifera a reference phylum for evolution and bioprospecting: The power of marine genomics
0043 AU  - Müller, W.E.G.
0044 AU  - Schwertner, H.
0045 AU  - Müller, I.M.
0046 AU  - Müller, W.E.G.
0047 AB  - The term Urmetazoa, as the hypothetical metazoan ancestor, was introduced to highlight the finding that all metazoan phyla including the Porifera [sponges] derived from one common ancestor. Analyses of sponge genomes, from Demospongiae, Calcarea and Hexactinellida have permitted the reconstruction of the evolutionary trail from Fungi to Metazoa. This has provided evidence that the characteristic evolutionary novelties of Metazoa existing in Porifera share high sequence similarities and in some aspects also functional similarities to related polypeptides found in other metazoan phyla. It is surprising that the genome of Porifera is large and comprises substantially more genes than Protostomia and Deuterostomia. On the basis of solid taxonomy and ecological data, the high value of this phylum for human application becomes obvious especially with regard to the field of chemical ecology and the hope to find novel potential drugs for clinical use. In addition, the benefit of efforts in understanding molecular biodiversity with focus on sponges can be seen in the fact that these animals as "living fossils" allow to stethoscope into the past of our globe especially with respect to the evolution of Metazoa.
0048 JF  - Keio Journal of Medicine
0049 VL  - 53
0050 IS  - 3
0051 SP  - 159
0052 EP  - 165
0053 PY  - 2004///
0054 N1  - Times Cited: 0, Export Date: 12 November 2004, Record Source: Scopus
0055 ER  -