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0001 TY - JOUR 0002 T1 - A continuous flow system (CFS) for chronic exposure of aquatic organisms 0003 AU - Sanni, S. 0004 AU - ØYsæd, K.B. 0005 AU - Høivangli, V. 0006 AU - Gaudebert, B. 0007 AB - Effect studies on marine life are changing focus from acute lethal effects to long term sublethal effects. There is a need for laboratory test systems that can facilitate continuous supplies of test substances at sublethal concentrations. Stability and reproducibility of the test solutions and application of test substances in mixtures are required. With the Continuous Flow System (CFS) described, the aim has been to make a flexible tool adjustable to a wide range of studies. Thus, test solutions and dispersions of substances poorly miscible in water can be made in various ways, using different methods and devices for substance injection, mixing and further conditioning. More than one species of organisms can be tested simultaneously. The system can be run both with freshwater and seawater. Presently the system is used for bioaccumulation and biomarker studies related to impacts of oil industry discharges of produced water off shore. This paper presents the main features and functional parts of the system and some result examples. 0008 JF - Marine Environmental Research 0009 VL - 46 0010 IS - 1-5 0011 SP - 97 0012 EP - 101 0013 PY - 1998/// 0014 KW - biological marker 0015 KW - fresh water 0016 KW - industrial effluent 0017 KW - sea water 0018 KW - ecotoxicology 0019 KW - laboratory method 0020 KW - pollution effect 0021 KW - sublethal effect 0022 KW - aquatic fauna 0023 KW - aquatic flora 0024 KW - bioaccumulation 0025 KW - conference paper 0026 KW - environmental monitoring 0027 KW - flow 0028 KW - laboratory test 0029 KW - long term exposure 0030 KW - nonhuman 0031 KW - oil industry 0032 KW - reproducibility 0033 N1 - Times Cited: 7, Export Date: 12 November 2004, Record Source: Scopus 0034 ER - 0035 0036 TY - JOUR 0037 KW - Bioactive compounds 0038 KW - Bioprospecting 0039 KW - Evolution 0040 KW - Metazoa 0041 KW - Urmetazoa 0042 T1 - Porifera a reference phylum for evolution and bioprospecting: The power of marine genomics 0043 AU - Müller, W.E.G. 0044 AU - Schwertner, H. 0045 AU - Müller, I.M. 0046 AU - Müller, W.E.G. 0047 AB - The term Urmetazoa, as the hypothetical metazoan ancestor, was introduced to highlight the finding that all metazoan phyla including the Porifera [sponges] derived from one common ancestor. Analyses of sponge genomes, from Demospongiae, Calcarea and Hexactinellida have permitted the reconstruction of the evolutionary trail from Fungi to Metazoa. This has provided evidence that the characteristic evolutionary novelties of Metazoa existing in Porifera share high sequence similarities and in some aspects also functional similarities to related polypeptides found in other metazoan phyla. It is surprising that the genome of Porifera is large and comprises substantially more genes than Protostomia and Deuterostomia. On the basis of solid taxonomy and ecological data, the high value of this phylum for human application becomes obvious especially with regard to the field of chemical ecology and the hope to find novel potential drugs for clinical use. In addition, the benefit of efforts in understanding molecular biodiversity with focus on sponges can be seen in the fact that these animals as "living fossils" allow to stethoscope into the past of our globe especially with respect to the evolution of Metazoa. 0048 JF - Keio Journal of Medicine 0049 VL - 53 0050 IS - 3 0051 SP - 159 0052 EP - 165 0053 PY - 2004/// 0054 N1 - Times Cited: 0, Export Date: 12 November 2004, Record Source: Scopus 0055 ER -